Air Quality Research Abstracts

EXHIBIT A

SELECTED ABSTRACTS since mid-2005 on traffic, air pollution, and public health

1. "Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus

traffic"

By Ryan PH, LeMasters G, Biagini J, Bernstein D, Grinshpun SA, Shukla R, Wilson K, Villareal

M, Burkle J, Lockey J. J Allergy Clin Immunol. 2005 Aug;116(2):279-84

Correspondence: at Department of Environmental Health, University of

Cincinnati, Cincinnati, OH 45267-0056, USA.

BACKGROUND: Previous studies of air pollution have not examined the association between

exposure to varying types, distance, and amounts of traffic and wheezing in very young infants.

OBJECTIVE: We sought to determine the relationship between types of traffic, traffic volume,

and distance and wheezing among infants less than 1 year of age. METHODS: A geographic

information system and a classification scheme were developed to categorize infants enrolled in

the study as living near moving truck and bus traffic (highway >50 miles per hour, >1000 trucks

daily, <400 m), stop-and-go truck and bus traffic (<50 miles per hour, <100 m), or unexposed

and not residing near either. Symptom data were based on health questionnaires administered to

parents when the infants were 6 months of age and monthly health diaries. RESULTS: Infants

living very near (<100 m) stop-and-go bus and truck traffic had a significantly increased

prevalence of wheezing (adjusted odds ratio, 2.50; 95% CI, 1.15-5.42) when compared with

unexposed infants. The prevalence of wheezing among nonwhite infants was at least twice that

of white infants, regardless of exposure. Infants living less than 400 m from a high volume of

moving traffic, however, did not have an increased prevalence of wheezing.

CONCLUSION:

These results suggest that the distance from and type of traffic exposures are more significant

risk factors than traffic volume for wheezing in early infancy.

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2 "Spatial Analysis of Air Pollution and Mortality in Los Angeles"

By Jerrett, Michael; Burnett, Richard T; Ma, Renjun; Pope, C Arden III ; Krewski, Daniel;

Newbold, K Bruce; Thurston, George; Shi, Yuanli; Finkelstein, Norm; Calle, Eugenia E; Thun,

Michael J.

Epidemiology. 16(6):727-736, November 2005.

Abstract:

Background: The assessment of air pollution exposure using only community average

concentrations may lead to measurement error that lowers estimates of the health burden Exhibit A on Air Quality: Selected Abstracts Since Mid-2005

CPA GPUC re: Proposed Conservation Element Update – Air Quality Chapter

attributable to poor air quality. To test this hypothesis, we modeled the association between air

pollution and mortality using small-area exposure measures in Los Angeles, California.

Methods: Data on 22,905 subjects were extracted from the American Cancer Society cohort for

the period 1982-2000 (5,856 deaths). Pollution exposures were interpolated from 23 fine particle

(PM2.5) and 42 ozone (O3) fixed-site monitors. Proximity to expressways was tested as a

measure of traffic pollution. We assessed associations in standard and spatial multilevel Cox

regression models.

Results: After controlling for 44 individual covariates, all-cause mortality had a relative risk

(RR) of 1.17 (95% confidence interval = 1.05-1.30) for an increase of 10 [mu]g/m3 PM2.5 and a

RR of 1.11 (0.99-1.25) with maximal control for both individual and contextual confounders.

The RRs for mortality resulting from ischemic heart disease and lung cancer deaths were

elevated, in the range of 1.24-1.6, depending on the model used. These PM results were robust to

adjustments for O3 and expressway exposure.

Conclusion: Our results suggest the chronic health effects associated with within-city gradients

in exposure to PM2.5 may be even larger than previously reported across metropolitan areas. We

observed effects nearly 3 times greater than in models relying on comparisons between

communities. We also found specificity in cause of death, with PM2.5 associated more strongly

with ischemic heart disease than with cardiopulmonary or all-cause mortality.

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3. "Traffic, Susceptibility, and Childhood Asthma"

By Rob McConnell,Kiros Berhane,Ling Yao, Michael Jerrett, Fred Lurmann, Frank Gilliland,

Nino Künzli, Jim Gauderman, Ed Avol, Duncan Thomas, and John Peters

Environmental Health Perspectives Volume 114, Number 5, May 2006

Address correspondence to R. McConnell, Department of Preventive Medicine, USC Keck

School of Medicine, 1540 Alcazar St., CHP 236, Los Angeles, CA 90033 USA. Telephone:

(323) 442-1096. Fax: (323) 442-3272. E-mail:

Abstract

Results from studies of traffic and childhood asthma have been inconsistent, but there has been

little systematic evaluation of susceptible subgroups. In this study, we examined the relationship

of local traffic-related exposure and asthma and wheeze in southern California school children

(5-7 years of age). Lifetime history of doctor-diagnosed asthma and prevalent asthma and

wheeze were evaluated by questionnaire. Parental history of asthma and child's history of allergic

symptoms, sex, and early-life exposure (residence at the same home since 2 years of age) were

examined as susceptibility factors. Residential exposure was assessed by proximity to a major

road and by modeling exposure to local traffic-related pollutants. Residence within 75 m of a

major road was associated with an increased risk of lifetime asthma [odds ratio (OR) = 1.29;

95% confidence interval (CI), 1.01-1.86], prevalent asthma (OR = 1.50; 95% CI, 1.16-1.95) , and

wheeze (OR = 1.40 ; 95% CI, 1.09-1.78) . Susceptibility increased in long-term residents with no Exhibit A on Air Quality: Selected Abstracts Since Mid-2005

CPA GPUC re: Proposed Conservation Element Update – Air Quality Chapter

parental history of asthma for lifetime asthma (OR = 1.85; 95% CI, 1.11-3.09), prevalent asthma

(OR = 2.46; 95% CI, 0.48-4.09), and recent wheeze (OR = 2.74; 95% CI, 1.71-4.39). The higher

risk of asthma near a major road decreased to background rates at 150-200 m from the road. In

children with a parental history of asthma and in children moving to the residence after 2 years

of age, there was no increased risk associated with exposure. Effect of residential proximity to

roadways was also larger in girls. A similar pattern of effects was observed with traffic-modeled

exposure. These results indicate that residence near a major road is associated with asthma. The

reason for larger effects in those with no parental history of asthma merits further investigation.

Key words: air pollution, asthma, child, epidemiology, traffic.

Concluding paragraph of article

We conclude that living in a residence with more nearby traffic increases the risk of childhood

asthma. Children with no parental history of asthma who had long-term residential exposure (or

early-life exposure) constituted a susceptible population, and the risk was larger for girls than for

boys. Because a substantial number of southern California children live near a major road, this

exposure is potentially an important public health problem that could be remediable by

transportation and residential development policy and by more effective control of vehicular

emissions. Among those long-term residents with no parental history of asthma who lived within

75 m of a major road, 59% of asthma was attributable to residential proximity to the road.

Further investigation is warranted to understand why the absence of parental asthma history

increased susceptibility to traffic-related exposure.

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4. "Traffic-Related Air Pollution and Otitis Media"

By Michael Brauer, Ulrike Gehring, Bert Brunekreef, Johan de Jongste, Jorrit Gerritsen,

Maroeska Rovers, Heinz-Erich Wichmann, Alet Wijga, and Joachim Heinrich

Environ Health Perspect. 2006 September; 114(9): 1414–1418.

Published online 2006 April 26. doi: 10.1289/ehp.9089.

Address correspondence to M. Brauer, School of Occupational and Environmental Hygiene,

University of British Columbia, 3rd Floor, 2206 East Mall, Vancouver BC V6T1Z3 Canada.

Telephone (604) 822-9585. Fax: (604) 822-9588. E-mail:

Abstract

Background. Otitis media is one of the most common infections in young children. Although

exposure to environmental tobacco smoke is a known risk factor associated with otitis media,

little information is available regarding the potential association with air pollution.

Objective. We set out to study the relationship between exposure to traffic-related air pollution

and otitis media in two birth cohorts. Exhibit A on Air Quality: Selected Abstracts Since Mid-2005

CPA GPUC re: Proposed Conservation Element Update – Air Quality Chapter

Methods. Individual estimates of outdoor concentrations of traffic-related air pollutants—

nitrogen dioxide, fine particles [particulate matter with aerodynamic diameters ≤ 2.5 µm

(PM2.5)], and elemental carbon—were calculated for home addresses of approximately 3,700

and 650 infants from birth cohort studies in the Netherlands and Germany, respectively. Air

pollution exposure was analyzed in relation to physician diagnosis of otitis media in the first 2

years of life.

Results. Odds ratios (adjusted for known major risk factors) for otitis media indicated positive

associations with traffic-related air pollutants. An increase in 3 µg/m3 PM2.5, 0.5 µg/m3

elemental carbon, and 10 µg/m3 NO2 was associated with odds ratios of 1.13 (95% confidence

interval, 1.00–1.27), 1.10 (1.00–1.22), and 1.14 (1.03–1.27) in the Netherlands and 1.24 (0.84–

1.83), 1.10 (0.86–1.41), and 1.14 (0.87–1.49) in Germany, respectively.

Conclusions. These findings indicate an association between exposure to traffic-related air

pollutants and the incidence of otitis media. Given the ubiquitous nature of air pollution exposure

and the importance of otitis media to children’s health, these findings have significant public

health implications.

Keywords: air pollution, cohort studies, infant, otitis media, vehicle emissions

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5. "Effect of exposure to traffic on lung development from 10 to 18 years of age:

a cohort study"

By W James Gauderman, Hita Vora, Rob McConnell, Kiros Berhane, Frank Gilliland, Duncan

Thomas, Fred Lurmann, Edward Avol, Nino Kunzli, Michael Jerrett, John Peters

Published online January 26, 2007 DOI:10.1016/S0140-6736(07)60037-3

Correspondence to: Dr W James Gauderman

Department of Preventive Medicine,University of Southern California,

1540 Alcazar Street,Suite 220, Los Angeles,CA 90033,USA

Summary

Background: Whether local exposure to major roadways adversely affects lung-function growth

during the period of rapid lung development that takes place between 10 and 18 years of age is

unknown.This study investigated the association between residential exposure to traffic and 8-

year lung-function growth.

Methods: In this prospective study,3677 children (mean age 10 years [SD 0 ·44]) participated

from 12 southern California communities that represent a wide range in regional air

quality.Children were followed up for 8 years, with yearly lung-function measurements recorded.

For each child, we identified several indicators of residential exposure to traffic from large roads.

Regression analysis was used to establish whether 8-year growth in lung function was associated

with local traffic exposure,and whether local traffc effects were independent of regional air

quality. Exhibit A on Air Quality: Selected Abstracts Since Mid-2005

CPA GPUC re: Proposed Conservation Element Update – Air Quality Chapter

Findings: Children who lived within 500 m of a freeway (motorway)had substantial deficits in

8-year growth of forced expiratory volume in 1 s (FEV1,–81 mL,p=0 ·01 [95%CI –143 to –18

])and maximum midexpiratory . ow rate (MMEF, –127 mL/s,p=0 ·03 [–243 to –11),compared

with children who lived at least 1500 m from a freeway.Joint models showed that both local

exposure to freeways and regional air pollution had detrimental,and independent,effects on lungfunction

growth.Pronounced deficits in attained lung function at age 18 years were recorded for

those living within 500 m of a freeway,with mean percent-predicted 97 ·0%for FEV1 (p=0

·013,relative to >1500 m [95%CIv94 ·6 –99 ·4 ])and 93 ·4%for MMEF (p=0 ·006 [95%CI 89 ·1 –

97 ·7 ]).

Interpretation: Local exposure to traffic on a freeway has adverse effects on children’s lung

development,which are independent of regional air quality,and which could result in important

deficits in attained lung function in later life.

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6. Effects of Subchronic and Chronic Exposure to Ambient Air Pollutants on Infant

Bronchiolitis

By Catherine Karr, Thomas Lumley, Astrid Schreuder, Robert Davis, Timothy Larson, Beate

Ritz and Joel Kaufman

American Journal of Epidemiology

Advance Access originally published online on December 8, 2006

American Journal of Epidemiology 2007 165(5):553-560;

Correspondence to Dr. Catherine Karr, Box 359739, Occupational and Environmental Medicine

Program, University of Washington, Pat Steel Building, 401 Broadway, Room 5079, Seattle,

WA 98104 (e-mail: ckarr@u.washington.edu).

Received for publication September 17, 2005. Accepted for publication July 21, 2006.

Abstract

Ambient air pollutant exposure has been linked to childhood respiratory disease, but infants have

received little study. The authors tested the hypotheses that subchronic and chronic exposure to

fine particulate matter (particulate matter ≤2.5 µm in aerodynamic diameter (PM2.5)), nitrogen

dioxide, carbon monoxide, and ozone increases risk of severe infant bronchiolitis requiring

hospitalization. Study subjects were derived from linked birth–hospital-discharge records of

infants born in 1995–2000 in the South Coast Air Basin of California. Cases with a hospital

discharge for bronchiolitis in infancy were matched to 10 age- and gestational-age-matched

controls. Exposures in the month prior to hospitalization (subchronic) and mean lifetime

exposure (chronic) referenced to the case diagnosis date were assessed on the basis of data

derived from the California Air Resources Board. In conditional logistic regression, only

subchronic and chronic PM2.5 exposures were associated with increased risk of bronchiolitis Exhibit A on Air Quality: Selected Abstracts Since Mid-2005

CPA GPUC re: Proposed Conservation Element Update – Air Quality Chapter

hospitalization after adjustment for confounders (per 10-µg/m3 increase, adjusted odds ratio =

1.09 (95% confidence interval: 1.04, 1.14) for both). Ozone was associated with reduced risk in

the single-pollutant model, but this relation did not persist in multipollutant models including

PM2.5. These unique US data suggest that infant bronchiolitis may be added to the list of

adverse effects of PM2.5 exposure.

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7. Associations of Fine and Ultrafine Particulate Air Pollution With Stroke Mortality in

an Area of Low Air Pollution Levels

Jaana Kettunen, MSc; Timo Lanki, MSc; Pekka Tiittanen, MSc; Pasi P. Aalto, PhD; Tarja

Koskentalo, MSc; Markku Kulmala, PhD; Veikko Salomaa, PhD Juha Pekkanen, MD

Stroke. 2007;38:918.

Correspondence to Jaana Kettunen, National Public Health Institute (KTL), Environmental

Epidemiology Unit, PO Box 95, FIN-70701 Kuopio, Finland. E-mail

Background and Purpose— Daily variation in outdoor concentrations of inhalable particles

(PM10 <10 µm in diameter) has been associated with fatal and nonfatal stroke. Toxicological

and epidemiological studies suggest that smaller, combustion-related particles are especially

harmful. We therefore evaluated the effects of several particle measures including, for the first

time to our knowledge, ultrafine particles (<0.1 µm) on stroke.

Methods— Levels of particulate and gaseous air pollution were measured in 1998 to 2004 at

central outdoor monitoring sites in Helsinki. Associations between daily levels of air pollutants

and deaths caused by stroke among persons aged 65 years or older were evaluated in warm and

cold seasons using Poisson regression.

Results— There was a total of 1304 and 1961 deaths from stroke in warm and cold seasons,

respectively. During the warm season, there were positive associations of stroke mortality with

current- and previous-day levels of fine particles (<2.5 µm, PM2.5) (6.9%; 95% CI, 0.8% to

13.8%; and 7.4%; 95% CI, 1.3% to 13.8% for an interquartile increase in PM2.5) and previousday

levels of ultrafine particles (8.5%; 95% CI, –1.2% to 19.1%) and carbon monoxide (8.3;

95% CI, 0.6 to 16.6). Associations for fine particles were mostly independent of other pollutants.

There were no associations in the cold season.

Conclusions— Our results suggest that especially PM2.5, but also ultrafine particles and carbon

monoxide, are associated with increased risk of fatal stroke, but only during the warm season.

The effect of season might be attributable to seasonal differences in exposure or air pollution